An environmentally friendly acylation reaction of 2-methylnaphthalene in solvent-free condition in a micro-channel reactor

An environmentally friendly acylation reaction of 2-methylnaphthalene in solvent-free condition in a micro-channel reactor

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An efficient and solvent-free acylation of 2-methylnaphthalene (2-MN) is presented using acid chloride as Queen Set both the acylating agent and solvent in a micro channel reactor.The effect of the catalyst, reactant ratio, mixing temperature, reaction temperature and reaction time on the product yield and selectivity was investigated.At room temperature with a reaction time of only 15 min, the Shoes target product, 2-methyl-6-propionylnaphthalene (2,6-MPN), was obtained in 72.3% yield with 73.8% selectivity, and 2-methyl-6-acetylnaphthalene (2,6-MAN) was obtained in 54.

1% yield with 55.4% selectivity.The route of synthesis provides a more environmentally friendly and efficient method to prepare 2,6-MPN with no other toxic solvents and efficient mass transfer and heat transfer.